Antibodies are able to latch onto the antigens using a unique binding site, which then disables the invaders. ✅ The body wants to fight antigens off, so it recognizes these substances and starts making antibodies. These are harmful substances that come from outside the body, such as from viruses or bacteria. Now, there are different types of antigens, but, for our purposes here, let’s zoom in on foreign, disease-causing antigens. And antigens are substances that can stimulate the body’s production of antibodies. antigensĪntibodies are special protein molecules that the immune system produces in response to antigens. This immunity is usually indicated by the presence of a critical part of the immune system: antibodies. ✅ Your body has immunity when it is resistant to a particular disease. One major type of foreign substances the immune system fends off are pathogens: infectious agents, especially viruses and bacteria, that cause disease. It includes the thymus, spleen, lymph nodes and lymph tissue, stem cells, white blood cells, antibodies, and lymphokines. The immune system is an incredibly complex network of cells that identify and defend against foreign substances in your body. What is immunity?īefore we can discuss antibodies, we need to take a big-picture look at the immune system. Continuing our mission to keep you informed and up-to-date, we’re providing a primer to very complicated topics, and terms, in immunology-complete with a handy glossary to all things antibodies at the end and some checkmarks (✅) to help you digest the key takeaways along the way. It also includes serological tests to determine if a person has antibodies that can signal immunity to COVID-19.īut what does serological mean, and what are antibodies, for that matter? As the coronavirus pandemic evolves, we know that vocabulary and concepts evolve with it. This includes diagnostic testing to determine if one is infected with the virus that causes COVID-19. Testing continues to be a major story-and concern-amid the COVID-19 pandemic. Likely future trends are also discussed.Terms and concepts to understand coronavirus antibody testingīy John Kelly, Senior Research Editor at This article will review the technologies currently used to make monoclonal antibodies with particular emphasis on mammalian cell culture. Cell line creation is often the slowest step in this stage of process development. In addition to improving process/cost efficiencies, a second key area has been reducing the time taken to develop processes and produce the first material required for clinical testing and proof-of-principle. This success has resulted from improvements in expression technology and from process optimisation, especially the development of fed-batch cultures. This has been particularly successful in the upstream part of the process where productivity of cell cultures has improved 100 fold in the last 15 years. This has resulted in rapid expansion of global manufacturing capacity, an increase in size of reactors (up to 20,000 L) and a greatly increased effort to improve process efficiency with concomitant manufacturing cost reduction. The clinical and commercial success of monoclonal antibodies has led to the need for very large-scale production in mammalian cell culture.
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According to the social function, telling memory stories helps us to socialise and bond with others. Psychologists and cognitive scientists often talk about autobiographical memory as having (at least) three key functions.Īccording to the self function, we know who we are because of our past experiences. While our memory is critically important to us, individual memories do not drive our personality. We're capable of infinite memory, but where in the brain is it stored, and what parts help retrieve it?Ģ: Core memories don’t drive our personality And different memories might be relevant to us in different contexts, meaning we might bring to mind a different set of self-defining memories on different occasions. This is an enormous memory store with no known limits on size or capacity.įor this reason, we are not limited to just five (or 50) important life memories. So, do core memories actually exist? While we do use memories to construct a sense of self, and these memories support our psychological wellbeing, memory science suggests the notion of a “core memory” is faulty in five key ways.Īutobiographical memories (memories about our selves and our lives) are kept in our long-term memory. Typically these posts have a strong element of nostalgia and focus on small moments: watching Saturday morning cartoons, holding hands with a schoolyard crush, or splashing through the rain. Thousands of TikTok users have made “core memory” posts about salient memories (often from childhood), with more than 880 million views worldwide. The idea is that some specific events are so important, experiencing them instantly shapes your personality, behaviours and sense of self. First seen in the 2015 movie Inside Out, core memories are thought to be your five or so most important memories. The notion of “core memories” has become well known in popular culture. What are your core memories from childhood? Can you lock in a core memory by choice? What do your core memories say about you? The unwanted duplicate files are removed, and the cloud drive app will automatically detect and sync the changes, i.e. Or, you can choose a desired selection rule or select by hand.ġ0. This cloud duplicate file finder already automatically selects all duplicates for mass removal. Once the scan is done, you can view, sort and preview the detected duplicate files.Ĩ. Select your cloud drive in the sidebar and click Open.ħ. Download and install the Cisdem cloud duplicate finder. All your files including the duplicates are on your computer.Ĥ. Now you will see the cloud drive in File Explorer (Windows) or Finder (Mac). Once set up, it will automatically start syncing your entire cloud drive or specific folders in it (based on your preferences) to your computer.ģ. Most cloud storage providers provide official desktop apps.Ģ. Download and install the cloud drive app. Steps to use the cloud duplicate finder to delete cloud duplicate filesġ. The trick is to sync your cloud drive with your computer first, which is made easy thanks to your cloud drive’s desktop app. You can use it to effortlessly find and mass delete duplicate files in all popular cloud storage services.Ĭisdem Duplicate Finder can weed out duplicate files on computers, external storage devices, and cloud drives. The best cloud duplicate file finderĬisdem Duplicate Finder can identify duplicate photos, videos, songs, Word documents, PDFs, spreadsheets, archives and all other duplicate files. This part talks about the best desktop apps to remove duplicate files from most if not all cloud drives via Windows PC and Mac and how to do the removal. Permanently delete the selected duplicates or move them to a folder of your choosing. You can do it manually or by choosing a selection rule.ġ2. Now it’s time to select unwanted duplicate files to remove. You can preview a duplicate photo by highlighting it.ġ1. Enable the built-in preview feature by selecting the Preview checkbox. Once the process is done, CDF will list the found duplicate files in groups.ġ0. The time it will take depends on the number of files to scan.ĩ. Choose to find all types of duplicates or a specific type such as duplicate documents.Ĩ. Select the entire drive or specific folders to scan.ħ. Now the sidebar will display the drive and the folders within it. If you trust CloudDuplicateFinder, click Allow to authorize it to access your account.Ħ. In the sidebar on the left, click the Add New Drive button.ĥ. At the top of the page, choose the cloud storage service in which you want to find duplicates.Ĥ. Sign up using your Google or Microsoft account. On your desktop (recommended) or mobile browser, go to 2. How to use Cloud Duplicate Finder web appġ. If you trust it, you can allow the access and start using it.Ĭloud Duplicate Finder allows you to find duplicate files for free, but you need to pay to delete duplicates. Learn about the possible risks first!ĬDF states that it uses 256-bit encryption and never gains access to the actual content of your data. Once you grant the access, this third-party app will be able to see, edit and delete your files and folders. To deal with the duplicate files in a cloud drive, CDF needs to access the files and folders in the drive. Whether it’s safe depends on your need of safety. You can delete them permanently or move them to a folder. There are two ways for you to handle the found duplicates. It also comes with a similar photo finder, which can finds certain similar images.
During your multi-hour adventure, you’ll progress through four adult courses, each color coded to signify difficulty level. The entire course is set in the treetops with some challenges 80 feet above ground. In addition to the adventure course’s zip lines, you’ll also have to overcome various challenges including cargo nets, suspension bridges, swings and more. Located about 45 minutes north of Tampa in Brooksville, FLG X Adventure Course is Central Florida’s newest zip line spot. Memberships are also available.Ĩ1 Image credit: TreeHoppers Aerial Adventure Park FLG X Adventure Course in Brooksville Visit during extended hours on select weekends for a night climb when the course is illuminated with lights and the music is cranked up a little louder.Īdmission includes three hours of adventure and is $60.95/adults if you purchase the tickets online. The color-coded courses allow you to travel the park unguided.įear not though! There are park monitors and guides throughout to assist if the need arises, and your ticket includes a safety and orientation class. There are 8 courses including hundreds of different elements to explore, such as platforms, cables, wood, rope, barrels, and of course, zip lines! Each course is color coded to signify the level of difficulty from beginner to advanced. TreeHoppers is the largest aerial adventure park in Central Florida. Reservations are required.Ĩ1 Image credit: Empower Adventures Zip Lining at TreeHoppers Aerial Adventure Park in Dade City Pricing depends on the package that you choose, but tickets start at $79 per adult for a daytime adventure and $84 for moonlight and sunset tours. No need to bring your camera your guides will take pictures of you throughout the adventure. Other date-night approved experiences include the Sunset Zip Line Adventure (every weekend) and the Moonlight Zip Tour (select weekend nights).Įach tour is guided by a trained professional and varies by difficulty. If that is not enough adrenaline for you, consider adding the Leap of Faith to your package.ĭuring this extra challenge, you’ll climb up a 25-foot pole and then leap off, trusting the line as you fly through the air to safety. suspension bridge and multiple aerial challenges. The Zip Line Adventure is 2.5 hours long, full of 5 separate zip lines, a 200 ft. Ziplining Spots Around Tampa Bay Zip Lining at Empower Adventures in OldsmarĮmpower Adventures is an exciting zip line adventure park located in Oldsmar. Note: We recommend calling ahead or visiting each park’s website for safety details and additional information you may need to know before you go. Why choose another night of dinner and a movie? Go on a zip line adventure and fly through the air together! Wondering where you can go zip lining in Tampa Bay? There are a plethora of quiet and romantic places to go in the Tampa Bay area, but if you’re looking for heart thumping excitement, we say give zip lining a try! Zip lining is a unique way to spend time outdoors and see the sights from a whole new perspective. Not all computers USB ports are in spec and some may give slightly more than the 500mA needed. That would mean that the USB port is supplying enough current. It may be possible to see a 2.5" drive work with 1 connector. Which is why you see 2.5" drives with 2 USB connectors. USB can only provide 500mA or 2.5W per port. It's obvious that a 2.5" disk being smaller will not require as much power to spin the smaller platters. And even with a 100% efficient 12V boost circuit it can't supply sufficient power to start the drive spinning and maintain it. No, the problem is that the USB port cannot supply sufficient current to start spinning the larger drives and maintain that. It's possible to boost 5V to 12V using a boost regulator circuit. While it's true that 3.5" drives require a 12V line and USB supplies only 5V, this is not the main limiting factor. Inside the external usb enclosure are electronics that convert AC power to DC. Some external drives use an AC adaptor, some DC. The drives themselves require DC regulated power. It's not related to either AC or DC power. (NOTE: any modding or custom wiring is done at your own risk) Even if the labeled power consumption refers to the peak power requirements during spinup (rather than typical power requirements), we'll definitely need at least 5 USB 2.0 headers or 3 USB 3.0 headers to fully power the drive. This particular drive also requires 5V, 0.85A-which could be taken partially from the leftover power supplied by the first few USB headers. Assuming perfect power conversion efficiency, that means stepping up the voltage from at least 3 USB 2.0 headers (5V * 0.5A * 3 = 7.5W) or 2 USB 3.0 headers (5V * 0.9A * 2 = 9W). A drive on my desk right now is labeled 12V, 0.5A (i.e., 6W). As others have noted, any random consumer 3.5" drive might require 13W to initially spin up the hard drive. stepping up the voltage from several 5V USB headers - technically possible, but completely impractical on USB 2.0 or older ports (and still not very practical on USB 3.0).a battery pack - portable and easy to wire up, but probably not a good idea because you could lose data if the battery died.The obvious flaw with this approach is that it wouldn't be very convenient if you want to use the drive on a different computer, and would not work if you wanted to connect the drive to a laptop. a desktop computer's power supply - you could wire your own 12V adapter that goes from the 12V DC IN jack on your SATA to USB connector, to the 12V and ground leads on one of the power supply's MOLEX or SATA power connectors (in a desktop computer).an AC adapter that outputs 12V DC - this is what all the manufacturers do.You don't necessarily have to use an external AC adapter to supply the 12V for your 3.5" drive, but since USB only supplies 5V you need to get 12V from somewhere else, such as the following: The second issue is that 3.5" drives require both 12V and 5V DC power, whereas 2.5" drives only require 5V. As others have mentioned, the total power requirement for any consumer 3.5" desktop drive might be around 13W, which far exceeds what you can get out of a single USB port, which supplies 2.5W (5V * 0.5A). There are two issues at play: power consumption (in Watts) and the input voltages to the drive. And dev, you don’t fool us with these people reviewing giving five star reviews stroking your telling you not to worry about the poor reviews. Do yourself a favor, keep looking for a replacement if you have to go one by one, because this one does not cut it. I’m sick of this app, I thought it was the stock app that came with the phone, and although it probably did come with it I wasn’t even sure it was deletable until today because I never bothered to look. This is not a supermarket app with Coupons where when you’re scrolling you can accidentally activate something no loss no gain really. It should at the very least and I stress the very least ask you if you are sure you want to delete it. Left and right swiping to delete alarms really needs to go, it’s an appropriate tool for something this important. Additionally, I missed a doctors telehealth appointment this morning because of this app, which is why I’m here looking to download replacements. And sometimes the alarm goes off but it’s not a very low rate and we don’t know why. I don’t know what happened to this app in the last few years, but lately in just the last two weeks alone, I have “lost“ several alarms it disappeared mysteriously. Read the other reviews as of lately, they are right. Hope to see some updates soon, otherwise, everything else works pretty good. If I’m mowing the lawn or feeding the animals I’ll probably miss it because it will make a small noise and then just stay on my phone, but if I don’t look at it till I come back in the house to wash my hands, then I’ve missed it. Reminders and calendar events don’t always work because they don’t make enough noise. Yours on the other hand, works no matter what. And if my alarm is to remind me of something during the day, unless I keep the other app open all day, it won’t work. Yours works even if my phone is silent and I forgot to set, but it has to be for every Thursday, when the alarm I might need is for a meeting or a flight that is 3 weeks or a month away. My other alarm does that, but I have to remember to open it before I go to sleep. Some simple suggestions would be to add options to the alarm like to set it for every other Thursday, or for a specific date. I had to download a separate app for that, and I wish I didn’t have to do that. what I don’t use if for is an alarm because there are not enough features. I use this app for many things, timers, stopwatch etc. I think this app has just been neglected or de-prioritized and is in need of a little TLC by developers or more people are going to stop using it. Either way, after being a lifelong apple clock app user, I am considering deleting it and finding another one. I can’t remember when exactly I started noticing this but I think it may have been after an update. I now have to use multiple alarms, as I can never trust the snooze is going to work. I know lots of people use calendar reminders for this reason, but why not build in a calendar to make the alarm app more functional?Īnother issue I’ve noticed more recently is, the swipe to snooze is so touchy that more times than not the alarm doesn’t swipe down properly and turns off rather than showing the option to snooze or turn off. For example, when I find out I need to wake up early for a flight 3 Fridays from now, why don’t I have the option to set the alarm for the day I need it to go off? The current option forces you to set it for every Friday. It would also be nice to be able to set an alarm for a particular date rather than just the standard day of the week. It would be cool if there was a way to group alarms for various tasks/activities into folders. I’ve used this app for as long as I can remember and the long list of alarms I set for various reasons gets to be confusing. Setting up your Chrome and authentication to work with LastPass. How to change default browser in iPhone/iPad?.How to Allow or Block Pop-ups and Redirects in Chrome on Computer?.View Full Desktop Site on Chrome Android Phone.Fix: Resolving Host issue on Google Chrome.
Sling back high heel Square toe Stiletto heel Slip on Colour Light Blue. That's why we offer ultra comfortable flexible soles and Pillow Walk styles to inject comfort into your every step. Pair them with a power suit or tapered trousers for a killer look. Consider classic nudes & neutral colors to add lightness to your everyday, or forever-in-fashion black styles for a killer look.Ĭomfort is key when it comes to wearing heels (we know the feeling). BLUE MARY JANES, T-Strap Shoes, Light Blue Heels, Baby Blue Vegan Leather Heels, Low Block Heels, Wedding Shoes for Bride, Wedding Heels (3.3k) Sale Price 79.85 79.85 99.81 Original Price 99.81 (20 off) FREE shipping. These shoes are made of a glossy patent leather that is both. They give your bridal gown the finishing it deserves. Even if it’s light blue, navy, turquoise, royal blue, etc. Asides from that, all shades of blue shoes command attention when they step onto the center stage. A blue shoe is a fashionable preference for most females. There's no shortage of colours when it comes to our have-it-all heels. The Amera Light Blue Patent Block Heel Pumps are a chic and stylish addition to any wardrobe. Light Blue Strappy Heels (1 - 22 of 22 results) Price () Shipping All Sellers CULT GAIA SANDALS (40) vintage secondhand preloved pre-owned sky blue strappy wrap around bare kitten heels 'vicky', size 40eu, 7uk, 9us (194) 167. 21 Blue Wedding Shoes: Mind-Blowing Ideas + FAQs. In need of something a little more grounded? Opt for of-the-moment kitten heels for that perfect amount of extra height. +3 Katy Perry The Busy Bee Crisscross Slide 65.40 MSRP: 109.00 Marc Fisher LTD - Zala Pump. Heeled mules and strappy heels are also an excellent option to make an effortless style statement. Blue Women Block Heel Wedge Heel Navy Stacked Heel Pink Wedding Kitten Heel White Dress Purple Gold Katy Perry - The Busy Bee Crisscross Slide. From sky-high stilettos and strappy heeled sandals to closed toe heels and low-heel must-haves, youll adore our womens heels in black, white, red, silver and. For a major style boost, consider our heeled sandals or platform heels for women designed to turn heads. From classic pumps to ever-so-trendy block heels, discover the latest silhouettes to elevate your looks to new height (literally). Ready to fall head over heels? Our assortment of women's heels and stilettos come in a variety of trend-right silhouettes to meet your everyday and occasion needs. Note that it doesn’t matter yet what direction your ship is pointing, all that matters is the direction it is traveling, which is the prograde marker. In other words, your prograde marker should be right on top of your target marker. To reach your target, you just need to make sure you are heading in the direction of your target. Target is circular pink, anti-target is an upside-down Y, also pink. Now there are only four: prograde and retrograde, which are the same as always, and target and anti-target. Go to the orbital map, click on your target, and select “set as target.” This changes the markers on the navball. If you don’t see target, you forgot to set your target. It has three settings, “orbit,” “surface,” and “target.” It cycles through these each time you click on it. On the navball, click the little window at the top. Once you are within a few hundred kilometers, it is time to close the distance. Note also that their closest approach may not be where the “intersection” markers are.Įverything up to this point is covered in other tutorials. Don’t worry about this too much, but you do want your ship and the target to be heading in generally the same direction when they encounter. (All this is covered in orbital rendezvous tutorials.) If your target’s orbit is highly elliptical, it will be helpful to line up the apoapsides and periapsides with radial in/out burns. Then move the navigation point back and forth until the intersection points are within a few hundred kilometers. Start by matching orbital planes, then increase your apoapsis until it just touches your target’s orbit (or decrease your periapsis if your target is in a smaller orbit). If you are not already familiar with how to rendezvous in orbit, read Tutorial: The Berry Maneuver. But you don’t need to sit and wait till you coast to within a couple kilometers.) If fuel consumption is a big concern, then you can get closer. So if you are in two very tight orbits, you will have to be closer.) (It will cost more fuel to match speed and trajectory if you are this far away, but it is not enough to matter much. You can't point your ship at the target when it is a quarter way around its orbit in front of you. That is, you have to be basically on the same side of the planet going basically in the same direction. (Note however that the real question is the "angular" distance. You do need to approach the target, but if you get within 200 or 300 kilometers you are plenty close. Most tutorials or discussions you see talk about getting into a similar but slightly smaller or slightly larger orbit to catch up to your target, then wait till you are within a kilometer or two. Docking is very easy to do if you know how to use the navball. Q-Tip was one of the people that we met and took a liking to us and got us in the building to meet different people. Rush Management - what we would call RAL (Rush Associated Labels) back then - had many artists like Run-DMC, De La Soul, etc. One of them was Def Jam so we went up to Def Jam. We would look on the back of hip-hop albums that were out back then and get the addresses of the labels. We were real young and didn’t know too much about the business but we did know that we would have to go to record companies and have someone listen to our demo. And of course, we had to make a demo so we did ?. Havoc: We were figuring how to go about getting a record deal back when me and P first met and decided to become a group. Take me back to the beginning of Mobb Deep and your first attempts at acquiring a record deal. Its dark elements were the perfect soundtrack for a mid-90s walkthrough of North America’s largest housing projects, Queensbridge. Released April 25, 1995, The Infamous became a cornerstone of gutter gripping rhymes over production just as eerie. Q-Tip’s prowess and example helped Prodigy and Havoc put together their most critically acclaimed album to date and perhaps one of the darkest LPs the genre has ever experienced.īillboard recently spoke to the Infamous duo about their second album 20 years later. That same year the A Tribe Called Quest producer and Queensbridge duo began work on Mobb Deep’s Magnum Opus, The Infamous. It was then that their original mentor, Q-Tip, would fully reinstate himself within the Mobb camp. In early 1994, Prodigy and Havoc were dropped from their first record deal. Its adolescent nature was only fitting for how the duo spent their tenure at their first label home, 4th & B’way Records, admitting they were young and immature in retrospect. While it produced a couple of decent youth-inspired anthems, the Mobb’s first effort on wax was remembered as being more green than portraying anything from the dark side. They would become Mobb Deep and drop their debut album, Juvenile Hell, in 1993. Def Jam was the New York hip-hop machine and their tour guide was none other than Q-Tip.Ī year later the duo - now known as Prodigy and Havoc - dropped their Poetical Prophets moniker for something darker. Barely at legal driving age, the two emcees were being walked into a world they knew little about. After umpteen denials someone finally decided to give the youngsters - who called themselves Poetical Prophets at the time - a listen and invite them inside. |
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